Chicken Alfredo Casserole

Featured in: Cozy Everyday Dinners

This elegant baked pasta casserole combines tender chicken, al dente penne, and a luxurious homemade Alfredo sauce enriched with heavy cream and Parmesan cheese. The dish is topped with a generous layer of shredded mozzarella and baked until golden and bubbling. Simple to prepare and incredibly satisfying, it serves six and comes together in just 50 minutes, making it ideal for weeknight dinners or entertaining guests.

Updated on Sun, 18 Jan 2026 12:35:00 GMT
Golden-brown baked Chicken Alfredo Casserole with bubbling mozzarella, served from a rustic 9x13 dish.  Pin
Golden-brown baked Chicken Alfredo Casserole with bubbling mozzarella, served from a rustic 9x13 dish. | orchardcrust.com

My youngest used to wrinkle her nose at anything pasta related until one rainy Wednesday when I threw this casserole together with leftover chicken and whatever I had in the fridge. The smell of garlic and cream drew her into the kitchen before I even called for dinner. She took one bite, paused, then asked if we could have it again the next night. That kind of quiet victory matters more than any fancy recipe ever could.

I made this for my sisters family when she had her second baby, and her husband texted me later asking for the recipe, which never happens. He said their four year old ate it without negotiation, bribery, or tears. When a dish can feed exhausted parents and picky eaters at the same time, you keep it in rotation. I started doubling the batch after that, keeping one for us and freezing another for nights when even thinking feels like too much work.

Ingredients

  • Penne or ziti pasta: The tube shape holds onto the creamy sauce in a way that flat noodles just cant, and cooking it just to al dente prevents it from turning mushy in the oven.
  • Cooked chicken breast: Rotisserie chicken is my shortcut on busy nights, but leftover grilled or poached chicken works beautifully and adds a subtle smoky or herbaceous note depending on how it was seasoned.
  • Unsalted butter: This is where the garlic blooms and releases its sweetness without burning, creating the aromatic base that makes your kitchen smell like an Italian grandmothers.
  • Garlic cloves: Fresh garlic minced fine gives a mellow, sweet warmth that powdered garlic simply cannot replicate, especially when it sizzles gently in butter.
  • Heavy cream: The richness here is non negotiable for true Alfredo texture, though you can use half and half if you want something a bit lighter without losing too much creaminess.
  • Parmesan cheese: Freshly grated melts into the sauce without clumping, and the nutty, salty depth it adds is the backbone of the entire dish.
  • Salt and black pepper: Simple seasoning lets the cream and cheese shine, but dont skimp because under seasoned Alfredo tastes flat no matter how much cheese you add.
  • Ground nutmeg: Just a whisper of it adds mysterious warmth that people notice but cant quite name, making them wonder what your secret is.
  • Mozzarella cheese: It melts into those gorgeous golden bubbles on top and adds a stretchy, gooey quality that makes every serving look like it belongs in a magazine.
  • Fresh parsley: A handful of green at the end brightens the whole dish visually and adds a tiny hint of freshness that cuts through all that richness.

Instructions

Get the Oven Ready:
Preheat your oven to 375°F and grease a 9x13 inch baking dish with butter or a quick spray of oil. This prevents sticking and makes cleanup so much easier later.
Cook the Pasta:
Boil the pasta in generously salted water until its just al dente, with a slight firmness in the center. Drain it well and set it aside, knowing it will finish cooking in the oven surrounded by all that creamy sauce.
Start the Sauce:
Melt butter in a large saucepan over medium heat, then add the minced garlic and stir it around for about a minute until it smells sweet and nutty. Watch it closely because garlic can go from perfect to bitter in seconds.
Build the Alfredo:
Pour in the heavy cream and let it come to a gentle simmer, then stir in the Parmesan, salt, pepper, and nutmeg until the cheese melts into a silky, smooth sauce. Taste it now and adjust the seasoning if needed.
Combine Everything:
Add the cooked chicken and drained pasta directly into the sauce, stirring gently until every piece is coated in that creamy goodness. The pasta should look glossy and luxurious.
Assemble the Casserole:
Pour the whole mixture into your prepared baking dish, spreading it out evenly, then scatter the shredded mozzarella over the top in an even layer. Dont worry if it looks like a lot of cheese, thats exactly the point.
Bake Until Golden:
Slide the dish into the oven and bake for 25 to 30 minutes, until the cheese on top is bubbling and turning golden brown in spots. The edges should look slightly crispy and irresistible.
Rest and Serve:
Let the casserole sit for about 5 minutes after you pull it from the oven so the sauce can thicken up a bit. Sprinkle with fresh parsley if you have it, then serve while its still steaming.
Steaming Chicken Alfredo Casserole with penne, tender chicken, and creamy Parmesan sauce ready to serve.  Pin
Steaming Chicken Alfredo Casserole with penne, tender chicken, and creamy Parmesan sauce ready to serve. | orchardcrust.com

One Sunday my neighbor brought over a bottle of wine, and I pulled this casserole out of the oven just as she walked in. We stood in the kitchen with forks, eating straight from the dish while it was still too hot, laughing about how we were definitely old enough to use plates but choosing not to. She said it tasted like the kind of comfort you cant buy, only make. I think about that every time I slide it into the oven now.

Make Ahead and Storage

You can assemble this entire casserole up to a day in advance, cover it tightly with foil, and keep it in the fridge until youre ready to bake. Just add an extra 5 to 10 minutes to the baking time if youre starting from cold. Leftovers keep well in an airtight container for up to 3 days, and they reheat beautifully in the microwave or a low oven. I sometimes freeze individual portions in small containers, which makes for the fastest comfort meal on a hard day.

Variations to Try

Toss in steamed broccoli florets or wilted spinach before baking to sneak in some green without changing the spirit of the dish. Sautéed mushrooms add an earthy richness that pairs beautifully with the cream and cheese. If youre feeling adventurous, swap half the mozzarella for fontina or Gruyère, which melt into an even more complex, nutty topping. Some nights I add a pinch of red pepper flakes to the sauce for a subtle warmth that makes everyone ask what I did differently.

Serving Suggestions

This casserole is rich enough to be the main event, so I usually serve it with something light and crisp on the side. A simple green salad with lemon vinaigrette cuts through the creaminess perfectly. Garlic bread is delicious but honestly feels like overkill unless youre feeding a crowd of teenage boys. A chilled glass of Chardonnay or Pinot Grigio complements the buttery sauce without competing with it.

  • Pair with a Caesar salad for a classic Italian American dinner that feels like dining out.
  • Serve alongside roasted asparagus or green beans for a pop of color and a little crunch.
  • Have crusty bread on hand for anyone who wants to soak up every last bit of sauce from their plate.
Freshly baked Chicken Alfredo Casserole garnished with parsley, alongside a simple green salad on the side. Pin
Freshly baked Chicken Alfredo Casserole garnished with parsley, alongside a simple green salad on the side. | orchardcrust.com

This is the kind of recipe that grows with you, adapting to whatever you have on hand and whoever youre feeding. It never pretends to be fancy, but it always delivers exactly what you need.

Recipe Q&A

Can I prepare this casserole ahead of time?

Yes, you can assemble the casserole up to 24 hours in advance. Cover it with plastic wrap and refrigerate. Add 5-10 minutes to the baking time if baking directly from the refrigerator.

What type of pasta works best?

Penne and ziti are ideal because their tubular shape captures the creamy sauce perfectly. You can also use rigatoni or any short pasta that holds sauce well.

How do I achieve a golden cheese topping?

Use freshly shredded mozzarella rather than pre-shredded, which contains additives. For extra browning, finish under the broiler for 1-2 minutes after baking, watching carefully to prevent burning.

Can I use frozen chicken?

Yes, thaw frozen chicken completely and cook it thoroughly before dicing or shredding. Alternatively, rotisserie chicken is a convenient shortcut that works wonderfully.

What vegetables pair well with this dish?

Steamed broccoli, spinach, or sautéed mushrooms blend beautifully into the creamy sauce. You can fold them in during assembly or serve them on the side with a crisp green salad.

Is there a lighter version of this casserole?

Absolutely. Replace heavy cream with half-and-half or whole milk for a lighter option. You can also reduce the mozzarella topping or use part-skim varieties to lower fat content.

Chicken Alfredo Casserole

Rich and creamy baked pasta with tender chicken, silky Alfredo sauce, and melted mozzarella for the perfect comfort meal.

Prep time
20 min
Cook time
30 min
Overall time
50 min
Created by Ruby Hensley


Skill Level Easy

Cuisine Italian-American

Makes 6 Portions

Dietary Info None specified

What You Need

Pasta

01 12 oz penne or ziti pasta

Chicken

01 2 cups cooked chicken breast, diced or shredded

Sauce

01 2 tablespoons unsalted butter
02 3 cloves garlic, minced
03 2 cups heavy cream
04 1 cup freshly grated Parmesan cheese
05 1/2 teaspoon salt
06 1/4 teaspoon freshly ground black pepper
07 1/4 teaspoon ground nutmeg

Cheese Topping

01 2 cups shredded mozzarella cheese

Garnish

01 2 tablespoons fresh parsley, chopped

Steps

Step 01

Prepare baking dish: Preheat oven to 375°F. Grease a 9x13-inch baking dish with butter or cooking spray.

Step 02

Cook pasta: Bring a large pot of salted water to boil. Add pasta and cook until al dente. Drain and set aside.

Step 03

Create Alfredo sauce base: Melt butter in a large saucepan over medium heat. Add minced garlic and sauté for 1 minute until fragrant.

Step 04

Finish sauce: Pour heavy cream into the saucepan and bring to a gentle simmer. Add Parmesan cheese, salt, pepper, and nutmeg. Stir until smooth and cheese is fully melted.

Step 05

Combine ingredients: Add cooked chicken and drained pasta to the Alfredo sauce. Mix thoroughly to coat all pasta evenly.

Step 06

Assemble casserole: Transfer the pasta mixture to the prepared baking dish. Distribute shredded mozzarella cheese evenly across the top.

Step 07

Bake casserole: Bake for 25-30 minutes until mozzarella is bubbling and the top is golden brown.

Step 08

Rest and serve: Remove from oven and allow to stand for 5 minutes. Garnish with fresh parsley if desired before serving.

Needed Tools

  • Large pot
  • Saucepan
  • 9x13-inch baking dish
  • Mixing spoons
  • Colander

Allergen Warnings

Read ingredient labels to spot allergens. If unsure, consult your doctor or a specialist.
  • Contains milk and dairy products
  • Contains wheat and gluten
  • May contain eggs if using egg-based pasta

Nutrition Details (for each serving)

These figures are intended for reference—not as a substitute for medical guidance.
  • Calorie Count: 540
  • Fats: 28 g
  • Carbohydrates: 39 g
  • Proteins: 32 g